In the world of Gen V, parents consent to Vought International injecting their young children with Compound V. The hope is that their offspring then develop superhuman abilities when they reach a certain age. Although the goal is for the young Supes to become stars, Gen V’s season 1 finale reveals that these chosen youngsters may be doomed in an unexpected way.

Andre’s Father Suffered Brain Damage Because Of Compound V

Andre Anderson has lived his life in the shadow of his Supe father, but Polarity’s powers have come at a price. In Gen V season 1, Polarity suffers a seizure, resulting in his magnetic manipulation abilities going haywire. After Polarity undergoes a medical examination, an exposition-laden doctor explains that by using his powers throughout the decades, Polarity has been doing irreparable damage to his neural pathways. There is even an implication that Polarity’s reaction to Compound V could be passed onto his son, with Andre experiencing at least one of the same symptoms as his father.

Gen V avoids digging fully into the ramifications of Polarity’s diagnosis, but the impression given is that Polarity’s seizures are a side effect of his magnetism powers specifically, rather than a broader side effect of the Compound V drug. Nevertheless, Polarity’s condition does open up the possibility that other supes in The Boys will eventually suffer similar medical problems. Although Vought has been pumping V into kids for decades, Polarity is retired in Gen V. As the current supe generation grows older, cases like Polarity’s could become increasingly common.

Butcher’s The Boys Season 3 Story Already Teased A Larger Problem With Compound V

The Boys season 3 introduced V24, otherwise known as Temp-V, which provides superpowers for a limited period of time. While Butcher and Hughie made full use of Vought’s latest innovation, they later discovered that only a handful of V24 doses would result in irreversible brain injuries. Since V24 is closely modeled on the main Compound V drug, it stands to reason that the side effects would be alike for both. While Polarity’s seizures may have been triggered by his magnetism, therefore, it seems equally plausible that the root cause is actually the Compound V itself.